How NMN Improves Cognition?
Cognition is related to the brain activities and everyone knows that our brain is a really hungry organ. Brain mostly requires a steady flow of blood (cerebral blood flow) and 20% of the body’s oxygen which automatically decreases with age.
Resultantly, reverse cognitive decline occurs which impairs our thinking abilities, coordination and memory. In order to battle this problem, a vast range of studies have been conducted. Apart from cognition, the brain is also responsible for other things which include information storage and speech transmission. Being a part of the central nervous system, the brain is also interlinked with the spinal cord and nerves which is why our movements of limbs depend on this important organ.
Can NMN restore cognition?
There are some natural diet related solutions which enhance our cognitive abilities. However, in the medicinal field, nicotinamide mononucleotide dramatically boosts our cognition. The experiments on mice have revealed that the best NMN supplementation lowers the mitochondrial oxidative stress in the brain cells which increases the cognitive abilities.
As we age, the NAD+ levels start to get diminished and it is important to have it in abundance because NAD powers the mitochondria of the cells especially our brain. Mitochondria is the powerhouse of all cells and all activities within the cells are carried out with the help of the powerhouse. When the NAD decreases, the cellular functions and activities do not take place like before. Similarly, cognition will be lowered as well. This is why there has been an increase in the NAD+ repletion therapies to accelerate the low amount of the molecule. Let us not forget that NAD and NAD+ are produced by the NMN itself so the real winner is nicotinamide mononucleotide.
A specific number of mice were taken and they were injected with 500 mg NMN for a span of two weeks. During this time period, the cognition and motor coordination of mice was keenly observed. Mitochondrial development and oxidative stress was also monitored which are indirectly related to cognitive abilities. After two weeks, the potential benefits of NMN were revealed. The therapy of nicotinamide mononucleotide induces the production of Nitric acid that
regulates the cerebral blood flow. The increased blood flow means an increase in the cognition and cognitive functions. It also means that the brain will be provided with the rightful amount of nutrients and oxygen to retain the effective thought process. Nicotinamide Mononucleotide also washes out the toxic metabolites and harmful materials with the help of undisturbed blood flow. Moreover, it protects the blood vessels and the inner mechanism of the brain making sure that all processes are being carried out at a good pace. Since the motor coordination is improved as well, the mice were able to move around better and faster than before because of the enhanced gait performance. This is how the cognitive impairment in the aged mice was treated successfully. The surprisingly positive results of the experiment opens doors for the old people suffering from mental disabilities.